Author

Stuart L. Goldstein

2 papers indexed here

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Open access Sep 2026

Physiologically Based Pharmacokinetic Modeling to Characterize the Disposition of Topiramate in Children with and without Obesity

Abstract Topiramate (TPM) is used to treat seizures in adults and children ≥2 years. In children, TPM dosing is body weight based. It is unknown whether children with obesity may benefit from an alternative dosing strategy. We developed a novel physiologically based pharmacokinetic (PBPK) model for TPM that accounts fo...

Patricia D. Maglalang, D. Gonzalez, W. Muller et al. · Journal of clinical pharmaco... · 0 citations

#artificial intelligence Preprint Sep 2026

Rolling Day-Wise Mortality Prediction in Critically Ill Patients With AKI on CRRT Utilizing Machine Pressure Waveforms

This is the first patient-level mortality prediction incorporating CRRT machine data, turning a discarded bedside stream into a continuous risk signal, and SHAP attribution showed that circuit-instability descriptors raised the machine share of the top 15 combined-model features from 3 to 7 (20.0% to 46.7%).

S. I. Pranto, Joanna Yang, Joshua W. Lambert et al. · 0 citations