Su-Chi Lim

Association between urinary metabolomics and cognitive performance in Asians with type 2 diabetes.

BackgroundThere is an ongoing quest for novel biomarkers which may serve as therapeutic targets in cognitive impairment, alongside a growing appreciation of urinary metabolomics as a promising non-invasive approach to identify metabolic signature of Alzheimer's disease and other causes of dementia.ObjectiveWe studied w...

β-hydroxybutyrate as an early predictive biomarker of diabetes remission following intensive dietary intervention

Pathway‐Specific Polygenic Risk Score and Risk of Hyperglycaemic Progression in Patients With Type 2 Diabetes

Pathway‐specific polygenic risk scores (psPRS) provide insights into the heterogeneity of type 2 diabetes. We aim to study whether psPRS for beta cell dysfunction, obesity and metabolic syndrome associate with risk of hyperglycaemic progression in Southeast Asian patients with type 2 diabetes.

Genome-wide DNA methylation analysis revealed epigenetic mechanism underlying end-stage renal disease

A large-scale two-stage epigenome-wide association study of ESRD in two independent cohorts identifies 52 ESRD-associated differentially methylated CpG positions (ESRD DMPs) showing consistent association between the two cohorts and across diverse kidney diseases, implicating 144 candidate genes enriched in inflammator...

Proteomic signatures of loss of glycemic control in youth-onset type 2 diabetes in the TODAY study.

Novel proteins involved in axon guidance, immune response, inflammation, and metabolism associated with LOGC in youth-onset T2D with proteins demonstrating consistent associations across the lifespan and proteomic platforms are identified.

Plasma Proteins Associated With Incident Acute Myocardial Infarction in Asians With Type 2 Diabetes.

Plasma proteomics improves AMI risk stratification in T2D, and FGF5 may play a role in cardiovascular risk in Asian populations.