Su-Hyuk Ko

CELF2 promotes 4R Tau splicing via nuclear clustering and drives cognitive dysfunction in tauopathy models

Alternative splicing is a fundamental mechanism underlying protein diversity. The microtubule-associated protein tau (MAPT) undergoes age-associated alternative splicing of exon 10 to generate 3 R and 4 R isoforms, and disruption of the 4 R:3 R ratio is a central feature of tauopathies. However, the molecular mechanism...