Su-Jin Baek

Splice-altering TP53 missense mutations as drivers of dysfunction and targets for RNA-based therapy.

A reclassification of select p53 mutations from simple missense to splicing-disruptive mutations reveals their underlying loss-of-function mechanisms and highlights their therapeutic reversibility, presenting a novel framework for RNA-based therapeutic strategies aimed at correcting splicing defects in TP53-mutant canc...