Identifying targets and mechanisms of endocrine disruptor-induced sex-specific toxicity: Integration of network toxicology and medaka experimental evidence.
Endocrine-disrupting chemicals (EDCs), including di(2-ethylhexyl) phthalate (DEHP) and propylparaben (PrP), are widespread environmental contaminants with adverse effects on reproductive health. However, the mechanisms underlying their sex-specific toxicity, particularly under combined exposure, remain incompletely und...