Jul 2026
Discovery of natural product-derived rosavin as a programmed death-ligand 1 inhibitor for cancer immunotherapy.
Rosavin is identified as a privileged novel and unexpected scaffold for designing potent PD-1/PD-L1 modulators, offering promising candidates for cancer immunotherapy and exhibiting the unusual small-molecule property of inhibiting PD-L1 without inducing its dimerization.
Wei Zou, Tianle Li, Jacek Plewka et al.
· Phytomedicine · 0 citations