Increased morbidity and mortality are associated with iron overload in sickle cell disease (SCD). Renal iron accumulation, a direct consequence of intravascular hemolysis, occurs in both patients and murine model of SCD, and correlates with albuminuria, an early marker of kidney injury. We aimed to investigate the role...
Mohammad O. Sako, Bryant J. Kane, Michael Booze et al.· AJP - Renal Physiology· 0 citations
Chronic kidney disease of non-traditional origin disproportionately affects outdoor workers exposed to high environmental temperatures. Recurrent heat stress with dehydration (rHS) is a major contributor to kidney injury; however, the underlying mechanisms remain poorly understood. We aimed to develop and validate a re...
Hung Nguyen, A. Montgomery, Cassidy Rehage et al.· AJP - Renal Physiology· 0 citations
A disruption in ferritin handling and iron homeostasis in PKD is demonstrated, suggesting altered iron trafficking promotes localized oxidative stress and fibrosis contributing to disease progression.
Nicole Sommer, Sagine Placide, Elizabeth Weatherly et al.· AJP - Renal Physiology· 0 citations
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