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Suguru Yamamoto

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Open access Aug 2026

Constrictions and shear stress are key determinants of amyloidogenic light chain (AL) amyloidosis.

Amyloid fibrils, crystal-like aggregates of denatured proteins, form upon breakdown of supersaturation and underlie amyloidosis in diseases, such as Alzheimer's, Parkinson's, and amyloidogenic light chain (AL) disease. In AL amyloidosis, fibrils accumulate in the heart, where they are exposed to shear stress. To mimic...

Yuji Goto, Keiichi Yamaguchi, Kichitaro Nakajima et al. · 0 citations

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