Mechanistic Roles of Conserved Active-Site Residues in OXA-48 Carbapenem Hydrolysis.
Carbapenem-hydrolyzing class D β-lactamases are a major source of resistance to last resort β-lactam antibiotics. OXA-48 is a class D β-lactamase that hydrolyzes carbapenems through a catalytic mechanism involving a nucleophilic serine and a carboxylated lysine general base. To define the contributions of conserved act...