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Suhyun Kim

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Open access Jul 2026

Computational protein stability analysis of SCN1A missense variants reveals domain‐dependent stability patterns

Abstract Objective To determine whether computational protein‐stability predictions discriminate pathogenic from benign SCN1A missense variants, and to characterize the structural distribution of predicted destabilization among pathogenic variants. Methods On an AlphaFold3‐predicted Nav1.1 structure, FoldX, and Rosetta...

Y. Shim, E. Kang, Naeun Kwak et al. · 0 citations
Open access Jul 2026

FUS-driven zebrafish model of ALS identifies tribenzylamine as a candidate modulator of ALS-associated pathology.

Findings support the mtFUS zebrafish model as a useful platform for ALS drug discovery and identify tribenzylamine as a candidate modulator of ALS-associated phenotypes, with effects linked to transcriptomic remodeling and neuronally active sex steroid signaling.

Yongbo Seo, Jeonghyeon Lee, Yunkyoung Lee et al. · 0 citations

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