A minimal polymer physics model of MYC-harbouring COLO320-DM ecDNAs is developed, revealing universal polymer physics principles underlying ecDNA condensate organization, offering a mechanistic basis for selective oncogene amplification and potential advantages in cancer progression.
Extrachromosomal DNAs (ecDNAs) are circular DNA elements found in many human cancers, often carrying oncogenes and regulatory elements. In COLO320-DM colorectal cancer cells, MYC-harboring ecDNAs form nuclear clusters associated with oncogene overexpression, but the mechanisms underlying their aggregation and gene upre...
Mattia Conte, Lana Al Hasani, T. Matteuzzi et al.· Nature Communications· 0 citations
Motivated by the ubiquity of ramified fractal deposits in nature and engineered systems, we investigate the irreversible adsorption of diffusion-limited aggregation (DLA) clusters on a square lattice. We study the role of cluster shape diversity on jamming properties of the system by systematically controlling the numb...
Fahad Puthalath, D. Mandal, Sumanta Kundu· 0 citations
The theoretical, computational and cultural challenges that need to be overcome to gain an understanding of the biological mesoscale are described and potential solutions are offered.
Sarah Harris, Gianluca Lattanzi, Angelo Rosa et al.· Biophysical Journal· 0 citations
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