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Author

Sumeyye Koc

2 papers indexed here

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Open access Sep 2026

Disrupted TFEB/GDNF–cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice

ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetic...

Long-Ping Yao, Maryam Hatami, Sumeyye Koc et al. · 0 citations
Aug 2026

Comparative Evaluation of Cytotoxic, Genotoxic, and Apoptotic Effects of Naringenin and Naringenin-Oxime in Colorectal Cancer Cells.

Colorectal cancer (CRC) remains a major global health concern, accounting for 9.6% of all cancer cases and 9.3% of cancer-related deaths. Natural compounds with anticancer properties have gained increasing interest due to their potential for reduced toxicity. This study investigated the cytotoxic, genotoxic, and apopto...

K. Bozalı, Sumeyye Koc, B. Ozkan et al. · 0 citations

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