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Open access Oct 2026

Sensitivity to ATR-CHK1 pathway inhibition in MDS/AML is enhanced by SRSF2 mutations and reduced by RUNX1 loss.

SRSF2 mutations occur in 5-15% of acute myeloid leukemia (AML) and ~15% of myelodysplastic neoplasms (MDS), are enriched in elderly/secondary AML, and lack mutation-directed therapy. We aimed to identify vulnerabilities in MDS/AML with SRSF2 mutations. Ex vivo drug-sensitivity testing of bone marrow cells from AML pati...

S. Eldfors, Sumit Rai, Vineet Sharma et al. · 0 citations
Review Open access Sep 2026

Translational bioengineering perspectives on biosensors and nanorobotics for cancer theranostics

The convergence of diagnostics and therapeutics, known as cancer theranostics, has become the backbone of 21st-century precision oncology. In the past decade, exponential progress in the engineering of nano-biosensors, nanorobotic actuation, and molecular biomarker profiling has allowed for the interrogation of tumors...

Manvi Rawat, Murari Kumar Jha, P. K. Agrawal et al. · 0 citations

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