Aug 2026
Subthreshold early white-matter hyperintensity increase predicts accelerated hippocampal and whole-brain atrophy in anti-amyloid-β immunotherapy
Background Anti-amyloid-β (anti-Aβ) therapy slows cognitive decline but paradoxically accelerates whole-brain gray matter atrophy, complicating outcome prediction. Objective To identify early imaging markers that predict long-term prognoses. Methods This longitudinal cohort study prospectively enrolled participants wit...
Shiori Amemiya, Hidemasa Takao, Shoya Matsumoto et al.
· Journal of Alzheimer's Disea... · 0 citations