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Sun-Joo Lee

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Open access Sep 2026

MgATP/MgADP-dependent conformational dynamics and intrinsically disordered regions of vascular K ATP channels revealed by cryoEM

Vascular smooth muscle KATP channels, composed of the pore-forming Kir6.1 and regulatory SUR2B subunits, control vascular tone, dysfunction of which causes systemic disease. Vascular KATP is regulated by Mg-nucleotides, but the underlying structural mechanism has remained elusive. Here, we determined cryoEM structures...

C. M. Driggers, Yi-Ying Kuo, Zhong-Ying Yang et al. · 0 citations

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