Heat Shock Protein 90 as a Master Regulator of Multidrug Resistance: Small-molecule Inhibitors, Prodrugs, Hybrid Molecules, Antibody-drug Conjugates, and Nanotechnology-based Delivery Systems.
INTRODUCTION/OBJECTIVE Multidrug Resistance (MDR) remains a major obstacle to effective cancer chemotherapy, driven by multiple interconnected mechanisms, including overexpression of ATP-binding Cassette (ABC) transporters, enhanced DNA repair, apoptosis evasion, and protumorigenic microenvironmental factors. Heat Shoc...