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Author

Sung-Ki Lee

2 papers indexed here

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Open access Oct 2026

GOLDEN: Gene expression and allele-informed decomposition for genetic heterogeneity in spatial transcriptomic data

Motivation Spatial transcriptomics (ST) enables exploration of cellular interactions, including immune responses. However, current methods rely on pathologists, with limitations in addressing genetic heterogeneity, where niches harboring nonclonal cells, including placental or allograft tissues, are present. Decipherin...

Sangjeong Lee, Tae Lyun Ko, H. Heo et al. · 0 citations
Open access Aug 2026

All-trans retinoic acid suppresses CD8+ T-cell terminal exhaustion and potentiates anti-PD-1 therapy in glioblastoma

Findings establish ATRA as a modulator of CD8⁺ T-cell exhaustion through the induction of WNT/β-catenin-dependent TCF-1βBD expression, suggesting that ATRA has therapeutic potential for overcoming resistance to ICB in glioma.

In Kang, Yumin Kim, Byeonguk Kang et al. · 0 citations

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