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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Sung Wook Chi

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Open access Sep 2026

Dysregulated m6A via compensatory arginine methylation primes premalignancy in metabolic dysfunction–associated steatotic liver disease

Hepatocellular carcinoma (HCC) originates from premalignant disease-associated hepatocytes (daHeps) that emerge during the progression of metabolic dysfunction–associated steatotic liver disease (MASLD) to metabolic dysfunction–associated steatohepatitis (MASH). As daHeps are compensatorily primed by metabolic stress,...

Geun-Woo D. Kim, Dahee Choi, Soo-Young Kim et al. · 0 citations
Open access Jul 2026

abCRISPR: deep learning-based design of abasic gRNA sequences for specific CRISPR-Cas9 genome editing

Abstract Summary CRISPR-Cas9 has become a widely used tool for genome editing. However, its off-target cleavage caused by partial sequence matches with guide RNAs (gRNAs) remains a critical limitation. Recently, abasic gRNAs (ØXØ) have been developed to enhance target specificity, but their effects vary depending on th...

Geun-Woo D. Kim, Dowoon Gu, Mingyo Park et al. · 0 citations

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