Oct 2026
Clonal heterogeneity in human pancreatic ductal adenocarcinoma and its impact on tumor progression.
Despoina Kalfakakou, Daniel Cameron, Emily A. Kawaler et al.
· Nature Genetics · 0 citations
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Sep 2026
Abstract A059: MYC biomolecular condensates contribute to PDAC classical-to-basal transition and immune evasion
MYC is one of the most ubiquitous amplified oncogenes in human cancers. Roughly 30% of pancreatic adenocarcinoma (PDAC) samples show MYC amplification, which is associated with increased aggressiveness and drug resistance. Our recent single cell analysis of 62 primary PDAC showed that MYC amplification promotes class...
Qing Su, Andre Qin, Mark Zarate et al.
· Cancer Research · 0 citations
Sep 2026
Abstract PR015: Clonal Heterogeneity in Human Pancreatic Ductal Adenocarcinoma and Its Impact on Tumor Progression
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer characterized by profound desmoplasia and cellular heterogeneity, which cannot be fully resolved using traditional bulk sequencing approaches. To understand how this heterogeneity contributes to PDAC biology, we analyzed a large cohort of primary tumors...
Despoina Kalfakakou, Sungsik Kim, Li-Dong Wang et al.
· Cancer Research · 0 citations