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This study identifies an initial NOS1AP-binding compound and shows that it can alter a NOS1AP-containing protein complex in living cells, and provides a foundation for optimizing NOS1AP-directed compounds and developing delivery systems to enhance brain penetration, tumor-selective accumulation, and therapeutic exposur...
This review highlights how CAR-based strategies can be adapted across diverse disease settings by redirecting engineered immune responses toward disease-sustaining cellular compartments and position programmable cellular immunotherapy as a broadly adaptable platform for eliminating persistent pathological cells, remode...
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