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Author

Suresh Mahalingam

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Open access Sep 2026

Targeting conserved interaction surfaces of alphavirus nsP4 supports the rational design of live-attenuated vaccine candidates

ABSTRACT Alphaviruses are emerging arboviruses that pose a growing threat to global public health; however, effective interventions remain limited. Recent structural studies of the chikungunya virus (CHIKV) replicase core revealed that the viral RNA-dependent RNA polymerase nsP4 interacts with both nsP1 and nsP2 and is...

Xiao-Yao Yang, Evelin Väljaots, Kai-Yu Li et al. · 0 citations

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