Author

Suresh Satpati

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Aug 2026

Spatial biology reveals altered macrophage states in immunosuppressed non-melanoma skin cancer.

Overall immune-cell composition was largely preserved despite differences in immune-cell distribution, spatial organization, and T cell clonality, and multi-cohort validation across complementary spatial and single-cell platforms identified consistent alterations in innate-adaptive immune organization in immunosuppress...

Shorook Naara, V. Kochat, Xiayu Rao et al. · Cell · 1 citation

Jul 2026

The novel hypomethylating agent NTX-301 reprograms epigenetic and Hippo signaling pathways and exhibits pre-clinical activity in venetoclax-resistant and TP53-mutant AML.

Data suggest that NTX-301 exerts potent anti-leukemia activities superior to 5-AZA and synergizes with VEN in VEN-resistant and TP53-mutant AML, in part by suppressing DNMT1 and inducing DNA damage responses and apoptosis, by inducing p53 signaling and demethylating LATS1/2, thus activating Hippo signaling.

B. Carter, P. Mak, Suresh Satpati et al. · Clinical Cancer Research · 0 citations

Preprint Jul 2026

LATTICE: Graph Self-Supervised Learning for Multimodal Spatial Omics Integration

LATTICE demonstrated stable optimization behavior, reproducible embeddings across analysis seeds, and complete multimodal integration across all samples, position LATTICE as a practical and empirically grounded framework for multimodal spatial omics integration, while also highlighting the need for stronger supervision...

J. Dwarampudi, V. Kochat, Suresh Satpati et al. · 0 citations