Author

Susan L. Ackerman

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Open access Oct 2026

A hyperactivating mutation in formin-like 2 causes brain and vertebrae defects

Formins are a group of proteins that nucleate and polymerize actin monomers into filaments to promote cell morphology and migration. Mutations in formin-encoding genes cause a broad spectrum of human diseases, ranging from kidney disease to non-syndromic intellectual disability. Through a forward genetics screen, we id...

Benjamin L. Zaepfel, J. Tran, Thomas Jucius et al. · bioRxiv · 0 citations

Open access Oct 2026

tRNA dosage regulates lineage dependency and resistance in prostate cancer.

Lineage plasticity underlies therapeutic resistance in cancer1,2, yet the translational mechanisms that enable this phenotypic flexibility remain largely unknown. Here using prostate cancer as a model of lineage dependence, we performed unbiased small RNA sequencing and identified tRNA1Arg(UCU) as a regulator of lineag...

Y. Kim, Sonali Arora, D. Young et al. · Nature · 0 citations