High-Content Genotoxicity Analysis reveals clastogenic effects of low-concentrations per- and polyfluoroalkyl substances mixtures in Human breast epithelial cells.
A high-content analysis protocol to assess genotoxicity in human breast epithelial MCF-10A cells by combining micronucleus detection with γH2AX foci quantification demonstrates the potential of high-content, human cell-based approaches for efficient and mechanistically informative genotoxicity assessment.