Author

Susumu S. Kobayashi

2 papers indexed here

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Open access Oct 2026

Mitochondrial DNA abundance is a determinant of immunogenic cell death in cancer.

Cells experiencing mitochondrial stress can undergo apoptosis or cell death that triggers innate immune activation. We examined the mechanisms determining these distinct outcomes in cancer. Abundant mitochondrial DNA (mtDNA) and high expression of the cGAS-STING pathway were features of KRAS-mutant cancers. In a pharma...

Kosuke Tanaka, Y. Adachi, T. Irie et al. · Immunity · 0 citations

Oct 2026

Acute MCL1 Loss via Homoharringtonine-Mediated Translational Inhibition Enables Potent Apoptotic Synergy with BCLXL Blockade.

Antiapoptotic buffering in solid tumors is generally mediated by both BCLXL and MCL1, so that BH3 mimetic drugs targeting only one have limited efficacy. To identify agents that may sensitize tumors to BH3 mimetics targeting BCLXL, we screened prostate cancer cells against a panel of mitochondria-targeted drugs in comb...

Akira Ohtsu, Tatsuhiro Sawada, L. Poluben et al. · Cancer Letters · 0 citations