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Sutita Nasoontorn

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Open access Aug 2026

Discovery of Bis-Thiourea Derivatives as Human DNA Topoisomerase IIα Inhibitors with Potent Anticancer Effects

DNA topoisomerase IIα (Topo IIα) is essential for maintaining genomic stability during DNA replication and mitosis and is highly expressed in cancer cells, making it a promising target for anticancer therapy. In this study, bis-thiourea derivatives were investigated for their Topo IIα inhibitory activity and anticancer...

Sahachai Sabuakham, Sarunya Kitdumrongthum, Sutita Nasoontorn et al. · 0 citations

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