Clinical Efficacy of Photodynamic Therapy and 1% Metformin Gel as Adjuncts to Scaling and Root Planing in the Treatment of Periodontitis: A Randomised Clinical Trial
Introduction: Photodynamic Therapy (PDT) utilises lightactivated Photosensitisers (PSs) to generate Reactive Oxygen Species (ROS) disrupting bacterial biofilms and eliminating pathogens with minimal toxicity. Metformin enhances bacterial clearance, suppresses Lipopolysaccharide (LPS)- induced inflammation, and stimulat...