Sydney D Welch

Dissection and Engineering of Modular Polyketide Synthase Extender Unit Specificity Motifs

Polyketide synthases (PKSs) are privileged enzymatic platforms for generating natural products. Yet, efforts to redesign their acyltransferase (AT) domains for incorporation of non‐native extender units remain constrained by an incomplete understanding of the sequence elements that govern specificity. EryAT6 is the met...