Aug 2026
Triprolidine Interferes with α-Synuclein Fibrillation and Remodels Aggregate Structure via Conformational Modulation.
Parkinson's disease (PD) is characterized by the pathological aggregation of α-synuclein (α-syn) into β-sheet-rich fibrils, contributing to neuronal toxicity and oxidative stress. In this study, we investigated the inhibitory and disaggregating effects of Triprolidine (TC) on α-syn fibrillation through a combined exper...
Md Nadir Hassan, Murtaza Hussain, Faisal Nabi et al.
· Biochemistry · 0 citations