ABSTRACT Polyplexes are versatile, efficient nonviral vectors for gene-based therapies and offer safer alternatives to conventional viral delivery systems. Delivering nucleic acids, including DNA, RNA, and siRNA, remains challenging because of limited stability, cellular uptake, and intracellular trafficking. Formed th...
Hamaira Liaqat, Huma Hameed, Syed Muhammad Ahmad et al.· Polymer-Plastics Technology...· 0 citations
It is proposed that a systems-level approach can be taken where PD is understood as a disease characterized by the imbalance in proteostasis, and potential treatment modalities include small molecules targeting lysosome function, CMA enhancers, gene therapy, and antibodies against extracellular α-synuclein.
Maryam Jabeen, Huma Hameed, Syed Muhammad Ahmad et al.· Neuromolecular medicine· 0 citations
Overall, the Eu-S100@TCh/CS microbead system represents a rationally designed colon-targeted delivery platform with potential to improve local therapeutic efficacy and reduce systemic toxicity.
Huma Hameed, Syed Muhammad Ahmad, Shazia Akram Ghumman et al.· RSC Advances· 0 citations
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