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Sylvain Meloche

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Open access Oct 2026

Immune-Complex-Based In Vitro Deubiquitination Assay

Deubiquitinases (DUBs) are attractive therapeutic targets within the ubiquitin-proteasome system, in part because four of the five DUB subfamilies are cysteine proteases amenable to the development of potent, selective inhibitors, as recently demonstrated for USP7. Identifying DUBs that deubiquitylate and stabilize spe...

Florence Dô, Sylvain Meloche, M. Servant · 0 citations

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