Author

T. Alberio

3 papers indexed here

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Review Open access Oct 2026

Modeling Strategies for Neurodegenerative Diseases: In Vitro, In Vivo and In Silico Frameworks

Neurodegenerative diseases (NDs) comprise a heterogeneous group of disorders characterized by complex etiologies, multifactorial pathogenic mechanisms, and remarkable clinical and molecular variability. Their increasing prevalence poses an important challenge to healthcare systems, society and the global economy. Despi...

Francesca Martorella, C. Cigolini, Giorgia Pupo et al. · Biomedicines · 0 citations

Open access Sep 2026

Network-based gene prioritization using hybrid scoring for complex disease module discovery

Complex diseases arise from perturbations in interconnected biological networks rather than isolated genetic defects. Network-based approaches provide a systematic framework for understanding disease mechanisms through protein-protein interaction data, yet most existing methods are developed and validated on a single...

Sveva Bonomi, Loris Bottelli, E. Oltra et al. · Scientific Reports · 0 citations

Open access Jul 2026

Machine-learning-based pIC50 prediction identifies novel acetylcholinesterase inhibitors among FDA-approved drugs

Sensitivity analysis confirmed the robustness of the binary activity threshold across alternative cut-offs, and an ablation study demonstrated that the combined Mordred–Morgan feature set yields better cross-validation performance than either descriptor family alone.

Sveva Bonomi, Marco Buglione, Crescenzo Edoardo Mauriello et al. · Machine Learning: Health · 0 citations