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Author

T. Baram

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Open access Aug 2026

Disrupted neuropeptide-signaling drives enduring reward deficits after early-life stress

It is found CRH signaling via CRHR1 indeed disrupts reward behaviors in naïve mice, but is dysregulated in ‘anhedonic’ mice with a history of ELA, and activation of CRH receptor 2 (CRHR2) reverses anhedonia-like behaviors in adult ELA mice.

Matthew T. Birnie, Lara Taniguchi, Lia M. Harvey et al. · 0 citations
Review Aug 2026

The Importance of Predictability in the Early-Life Environment for Neurodevelopment and Mental Health

Predictability, the degree to which environmental inputs are structured, patterned, and reliably signaled over time, has emerged as a central dimension of early experience with unique implications for brain development, stress physiology, and mental health. This review synthesizes convergent evidence from human and ani...

Mason Hardy, T. Baram · 0 citations

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