Open access
Aug 2026
Methylation Mesa define functional regulatory elements for targeted gene activation
DNA methylation regulates transcription, yet the demethylation of canonical elements like promoter CpG islands exhibits inconsistent correlations with gene activation. We hypothesize that causal regulatory elements are defined by biophysical hypersensitivity. Profiling 24 whole-genome bisulfite sequencing samples acros...
Y.-V. Liu, J. Suryatenggara, H. Wong et al.
· Nature Communications · 0 citations