T. Benzinger

MRI Evaluation and Reporting in Suspected and Established Idiopathic Normal Pressure Hydrocephalus, AJR Expert Panel Review.

This AJR Expert Panel Narrative Review summarizes MRI features of idiopathic normal pressure hydrocephalus (iNPH) and their utility in various clinical scenarios, describes imaging features suggestive of alternate or co-pathology, and provides a framework for reporting such findings. iNPH is characterized by gait impai...

Technology‐natives and technology‐adopters: Age differences in remote cognitive assessment in Alzheimer disease

Cognitive changes in the asymptomatic stages of Alzheimer disease (AD) are subtle and difficult to detect using conventional cognitive tests. High‐frequency smartphone‐based testing may improve sensitivity to these changes, but generational differences in technology use could influence performance. We examined generati...

Dynamic changes in plasma biomarkers of Alzheimer's disease in patients treated with lecanemab: a longitudinal cohort study.

BACKGROUND Anti-amyloid antibodies slow cognitive and functional decline in individuals with early symptomatic Alzheimer's disease, but few studies have examined changes associated with these treatments in plasma biomarkers linked to neurodegeneration. We analysed changes in a panel of 130 plasma proteins and their ass...

Fluid biomarkers in the evolving care landscape of Alzheimer's disease and related disorders.