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T. Bharat

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Open access Sep 2026

The life cycle of an archaeon with multiple membranes

Many prokaryotes are diderms. They divide using an FtsZ division ring to simultaneously constrict physically coupled inner and outer membranes to form daughter cells with two membranes. Currently, only one archaeon, Ignicoccus hospitalis, is known to have an outer and inner membrane. Here, in exploring Ignicoccus cell...

Florian Mayer, Andriko von Kügelgen, Richard Stöckl et al. · 0 citations
Review Open access Sep 2026

Diverse S-layer anchoring mechanisms create an epiplasmic space in prokaryotic cell envelopes.

Surface layers (S-layers) are paracrystalline protein lattices that form the outermost boundary of many archaeal and bacterial cells. Interest in S-layer biology has grown rapidly in recent years, driven by advances in structural and bioinformatic studies that have revealed new insights into lattice organization and fu...

Buse Isbilir, T. Bharat, V. Alva · 0 citations
Open access Aug 2026

Molecular architecture of colossal surface layers from hyperthermophilic archaea

Surface layers (S-layers) are paracrystalline protein lattices that form the outermost layer of the cell envelope in most archaea, providing structural support, protecting against external insults, and co-ordinating interactions with their environment. Despite their widespread occurrence, the molecular and structural d...

I. Caspy, V. Cvirkaite-Krupovic, Sofie van Dorst et al. · 0 citations
Open access Jul 2026

Structural basis of biofilm formation mediated by the Pseudomonas aeruginosa fibrillar adhesin CdrA

An electron cryomicroscopy structure of the 60 kDa CdrA adhesive N-terminus is reported, which combined with electron cryotomography of focused-ion beam milled specimens, allows for a complete in situ model of the native adhesin and reveals a small adhesive domain (called ADEPT) at the distal tip of CdrA that is nearly...

Olivia E. R. Smith, Camila M. Clemente, Antonina Andreeva et al. · 0 citations
Open access Jul 2026

Eukaryotic-like microtubules and dynamic instability of Asgard archaeal tubulins

The possibility that microtubule architecture and dynamics evolved in Asgard archaea prior to eukaryogenesis is raised, as well as the broad occurrence of tubulins in Asgard archaea.

Jan Löwe, Andriko von Kügelgen, V. J. Planelles-Herrero et al. · 0 citations

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