Author

T. Brüning

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Review Open access Oct 2026

From Molecular Alterations to Risk Prediction: Biomarkers of Actinic Keratosis Progression to Cutaneous Squamous Cell Carcinoma

The high—and in most countries steadily increasing—incidence of cutaneous squamous cell carcinoma (cSCC) represents a growing public health challenge. As the majority of cSCCs arise from pre-existing actinic keratosis (AKs), these lesions are recognized as the principal precursors of invasive disease. A comprehensive u...

T. Meyer, Lea Stockfleth, K. Lang et al. · Cancers · 0 citations

Open access Oct 2026

Applicability of Human Oral Toxicokinetic Data for Human Biomonitoring of Dermal Exposure to 2-Ethylhexyl Salicylate (EHS).

2-Ethylhexyl salicylate (EHS) is a UV filter used in sunscreens and personal care products. Mixed-route exposure via both dermal and oral pathways is considered likely, and specific oxidative metabolites of EHS (i.e., 5OH-EHS and 5cx-EPS) in urine have been successfully established as exposure biomarkers for robust hum...

Katharina E. Ebert, H. Koch, T. Brüning et al. · Toxicology Letters · 0 citations

Aug 2026

Metabolism and urinary excretion kinetics of 2,4-di-tert-butylphenol after a single oral dose: Characterisation of suitable exposure biomarkers for human biomonitoring.

2,4-Di-tert-butylphenol (DTBP) is a degradation product of the antioxidant and plastic additive tris(2,4-di-tert-butylphenyl)phosphite. DTBP can migrate into food or drinking water from high production volume polyolefins containing this additive, leading to potential human exposures, confirmed by findings of DTBP in bl...

C. Schmidtkunz, Katharina E. Ebert, Isabell Schönrath et al. · Toxicology Letters · 0 citations