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Author

T. Brusko

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Open access Sep 2026

Immune dysregulation and stem-like CD8+ T cell enrichment in type 1 diabetes pancreatic lymph nodes

Effector CD8+ T cells are key drivers of type 1 diabetes (T1D) pathogenesis, yet questions remain regarding the molecular defects leading to altered cytotoxicity, peripheral tissue phenotype, and receptor specificity. We analyzed human pancreatic lymph nodes (pLNs) using mass cytometry and single-cell RNA-seq (scRNA-se...

Leeana D. Peters, Howard R. Seay, Justin A. Smith et al. · 1 citation
Open access Aug 2026

Bootstrap-enhanced regularization addressing multicollinearity and skewness in high-dimensional immunophenotyping data

The Bootstrap-Enhanced Regularization Method (BERM) is a robust approach for variable selection and coefficient estimation in complex biomedical datasets, achieving the highest overall balanced accuracy while maintaining competitive coefficient estimation performance across a range of simulated sparsity, noise, and dim...

Xiaoru Dong, Apoorva Goyal, Mu-Xuan Liang et al. · 0 citations

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