DNA double-strand breaks (DSBs) require rapid signalling and physical stabilisation of broken DNA ends to preserve genome integrity. Here, we identify myosin VI (MVI) as an ATM-regulated component of the DSB response. DNA damage induces rapid nuclear accumulation and nanoscale reorganisation of MVI across multiple cell...
Abdulmohsen Alanazi, Alexander W. Cook, Isabel W. Shahid-Fuente et al.· bioRxiv· 0 citations
The lifetime of fluorescent molecules provides an orthogonal readout to fluorescence intensity, opening experimental possibilities of measuring changes in local molecular environments, mechanical tension, and metabolism, among other factors. These changes are best studied live and in vivo; however, limitations of slow...
Chad M. Hobson, Owen F Puls, Jesse S. Aaron et al.· bioRxiv· 0 citations
An optical flow tool, called OpticalFlow3D, that can be run in Python or MATLAB and is compatible with three-dimensional microscopy images is described, to illustrate how OpticalFlow3D can enable new biological insight.
Rachel M. Lee, Leanna R Eisenman, Chad M. Hobson et al.· Journal of Cell Science· 1 citation
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