T. Chohan

Development of Sustained Release Chitosan/β-Glycerol Phosphate-Based Injectable Thermo-Gels Containing Naproxen Sodium: In-Vitro and In-Vivo Evaluation.

PURPOSE To develop in-situ chitosan/β-glycerol phosphate (β-GP) thermogels loaded with naproxen sodium for sustained drug delivery, to circumvent issues related with prolonged oral administration of naproxen (e.g. ulceration, abdominal discomfort, diarrhoea, bloating, etc.). To overcome these complications, in-situ gel...

Antimicrobial Peptides Targeting Salmonella enterica serovar Typhi: Mechanism of Action, Structural Insights, and Translational Challenges - A Review.

Unveiling the antioxidant and antimicrobial potential of Astragalus tephrosoides methanol extract: Phytochemical screening, GC-MS profiling, computational and experimental approaches.

This study evaluated the methanol extract of Astragalus tephrosoides to evaluate its phytochemical composition, biological activities and in-silico properties, and revealed bioactive compounds with promising antioxidant, antimicrobial and moderate phytotoxic activities.

Modeling Structure-Activity Relationships with Machine Learning to Identify DPP4 Inhibitors as potential Therapeutics for Type 2 Diabetes

Findings identify CP20 as a promising lead scaffold for the development of novel DPP4 inhibitors and demonstrate the effectiveness of an ensemble machine learning-guided computational framework for accelerating antidiabetic drug discovery.