Author

T. Fuerst

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Open access Aug 2026

The conserved bridging domain on HCV E1E2 glycoprotein complex is targeted by neutralizing antibodies from diverse lineages.

Describing the genetic, structural, functional, and epitope features of 25 BD-directed nAbs isolated from HCV-infected individuals or immunized macaques underscores BD as a promising target for rational HCV vaccine design.

Fang Chen, Yen Thi Kim Nguyen, Yi-Zong Lee et al. · Cell Reports · 0 citations

Open access Jul 2026

Induction of Robust Immunity Against Hepatitis C Virus Using Rationally Adjuvanted Microneedle Patches Integrating A Secreted Form of E1E2 Heterodimer 2259568

The preclinical development of a novel HCV vaccine candidate engineered by formulating a novel native-like secreted E1E2 immunogen and a well-established combinatorial adjuvant of QS-21 + 3D-(6-acyl) PHAD into unique microneedle patches (MNPs).

Yi-Nuo Zhang, A. Dhayani, Stephen C. Balmert et al. · Journal of Immunology · 0 citations