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T. Gao

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Open access Aug 2026

Low-heteroplasmy mitochondrial DNA mutations improve clonal reconstruction of human cells

Reconstructing clonal relationships among human cells is fundamental to understanding development, aging, and disease. Somatic mitochondrial DNA (mtDNA) mutations act as endogenous single-cell barcodes measurable alongside cell-state profiles, but lineage tracing has traditionally focused on high-heteroplasmy variants,...

Chen Weng, T. Gao, William N. Colgan et al. · 0 citations

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