Author

T. Grimmer

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Open access Oct 2026

Microglial dynamics associate with the spatial pattern of tau deposition in early Alzheimer’s disease

Neuroinflammation is implicated in Alzheimer’s disease (AD) pathogenesis, yet how changes in TSPO PET signal are associated with tau deposition, and how brain network architecture shapes this relationship remain poorly understood. We conducted a prospective, multimodal neuroimaging study in 56 participants: 35 amyloid-...

M. Öchsner, M. Brendel, N. Franzmeier et al. · Alzheimer's Research & Thera... · 0 citations

Open access Jul 2026

Deep learning‐based cortical thickness maps for diagnosis of neurodegenerative diseases: a rater study

Deep learning enables quantitative evaluation of cortical thickness (CTh) and z‐score maps, which are essential for diagnosing neurodegenerative diseases (NDs) but remain challenging to assess visually.

E. Riedel, Fabian Bongratz, B. Zott et al. · Alzheimer's & Dementia · 0 citations

Open access Sep 2026

APOE-stratified genome-wide association analyses provide insights into the genetic etiology of Alzheimers’s disease

Understanding of the genetic architecture of AD in the context of its main genetic driver is improved, and APOE-stratified insights may help understand and overcome side effects, inform clinical trial enrollment strategies, and create the scientific basis for targeted, mechanism-driven therapies in neurodegenerative di...

J. Thomassen, H. Leonard, Brittany Ulms et al. · Nature Genetics · 0 citations