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Author

T. Halazonetis

2 papers indexed here

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Open access Oct 2026

Integrating Fragment Screening and Covalent Chemistry to Drug DNA-Binding Proteins: RAD52 as a Case Study.

Protein-DNA interfaces are central to genome maintenance but remain challenging targets for small-molecule discovery because they are often broad, polar, solvent-exposed, and lack classical druggable pockets. Here, we establish a structure-guided strategy to chemically target such interfaces by combining the fragment-b...

Nicolas Bocquet, Alessandro Potenza, Jason Clochard et al. · 0 citations
Open access Sep 2026

Human POLD3 coordinates leading and lagging strand mitotic DNA synthesis

Cancer cells are characterized by the presence of oncogene-induced DNA replication stress. A common consequence of replication stress is failure to complete DNA replication in S-phase, in which case, DNA replication may be completed in mitosis by a variant of Break-Induced Replication (BIR) called Mitotic DNA Synthes...

Demetrio Turati, Vasilios S. Dionellis, L. Tropia et al. · 0 citations

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