Author

T. He

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Open access Sep 2026

The Edwardsiella T3SS effector EseJ enhances NF-κB signaling by stabilizing p65 and promoting TAK1 phosphorylation

Edwardsiella piscicida PPD130/91 is an important pathogen that infects both fish and humans. Upon infection, E. piscicida induces strong inflammatory responses through its type III secretion system (T3SS). The underlying mechanisms remain to be defined. Here, we demonstrate that E. piscicida T3SS effector EseJ activate...

Tian-Tian He, Pu-Yu Tang, Qian-Ru Zhao et al. · PLoS Pathogens · 0 citations

Open access Jul 2026

Hemolysin EthA is an Edwardsiella T3SS effector that induces PANoptosis in macrophages

Edwardsiella piscicida is an enteric intracellular bacterial pathogen. It has been reported that this bacterium produces two types of hemolysins: the secreted, pore-forming toxin HlyA and the cell-associated toxin EthA. EthA has been reported to enter epithelial cells by binding to outer membrane vesicles (OMVs) and th...

P. Tang, Xiulan Jiang, Xinyi Zhou et al. · Veterinary Research · 0 citations