Author

T. Johnston

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Open access Oct 2026

IL-6 Blockade with Clazakizumab is Associated with Low Myeloid Cell Activation and Increased Type 2 Immune Responses in Non-survivors of COVID-19.

BACKGROUND IL-6 inhibitors have been associated with reduced mortality in severe COVID-19 in randomized clinical trials, but the comprehensive immunological impact of IL-6 blockade in the setting of an acute viral infection is poorly understood. METHODS To gain insight into the systemic immune response to IL-6 inhibi...

Laila Stoddart, T. Johnston, Wei-Qiang Zhou et al. · Journal of Infectious Diseas... · 0 citations

Open access Jul 2026

Conserved CD4 T-cell responses correlate with antibody neutralization in solid organ transplant recipients after bivalent SARS-CoV-2 vaccination

The results emphasize the importance of conserved and cross-reactive responses in vaccine immunogenicity, providing a mechanism through which repeated boosting enhances vaccine immunogenicity in SOTRs and other immunocompromised populations.

Georgia Stavrakis, Katerina Roznik, Laila Stoddart et al. · Frontiers in Immunology · 0 citations