Abstract Background Bipolar disorders (BD) are associated with a wide range of brain white matter abnormalities, but results vary across studies. This heterogeneity likely relates to effects of additional clinical/diagnostic variables, including medications and obesity, on white matter in BD. In this mega-analysis, we...
Lorielle M. F. Dietze, Sean R. McWhinney, P. Favre et al.· Psychological Medicine· 0 citations
AIMS
To explore the dimensional structure of the Thought and Language Disorder scale (TALD) in a sample of acute psychiatric inpatients and to contribute to a characterization of the latent dimensions underlying formal thought disorder (FTD).
METHODS
A total of 250 acute patients with psychotic and affective disorder...
F. Dazzi, Isabella Getuli, Beatriz Alessandri Perez et al.· Schizophrenia Research· 0 citations
Language disturbances are prominent across psychiatric disorders, yet their underlying organization and relationship to clinical functioning remain poorly understood. We conceptualized spontaneous speech as a temporally evolving sequence of contextual representations through semantic space, in which successive concepts...
A. Korda, Christina Andreou, L. Mineur et al.· NPP—Digital Psychiatry and N...· 0 citations
Importance
Early identification of patients at high risk of relapse is key to personalized preventive strategies in major depressive disorder (MDD). However, current predictive models do not adequately account for the multimodal factors contributing to MDD relapse and fail to provide clinically meaningful predictions....
L. Teutenberg, N. Winter, P. Usemann et al.· JAMA psychiatry· 0 citations
Symptoms and psychosocial factors interact dynamically across affective and psychotic disorders, yet longitudinal evidence remains limited. Building on the network theory of psychopathology, this study conceptualizes mental disorders as systems shaped by symptom-environment interactions. Using data from a two-site Germ...
Rui Tan, F. Stein, L. Teutenberg et al.· European Archives of Psychia...· 0 citations
Biofluid proteins are promising transdiagnostic markers for delineating disease heterogeneity in psychosis. This study examined proteomic profiles in a transdiagnostic early psychosis sample to test the hypothesis that psychosis is associated with proteomic signatures of premature aging. We analyzed proteomic data from...
J. Seitz-Holland, M. Haaf, A. Mendes-Silva et al.· Brain, behavior, and immunit...· 0 citations
Depressive symptoms show an increased prevalence in individuals affected by spinal cord injury (SCI), yet their in-depth characterization and association with clinical outcomes remain underexplored. We investigated depressive symptoms, operationalized through the items in the Beck Depression Inventory (BDI), in a longi...
Roman Schefzik, L. Heutehaus, C. Schuld et al.· Scientific Reports· 0 citations
BACKGROUND
Negative expectations towards the future are frequently observed in patients with major depressive disorder (MDD) and linked to less favourable outcomes like worse treatment response and suicidal behaviours. Despite clinical significance, the neurobiological underpinnings of negative expectations remain larg...
Laila Noor, F. Stein, K. Brosch et al.· Journal of Affective Disorde...· 0 citations
BACKGROUND
Formal thought disorder (FTD) is a key determinant of social functioning in schizophrenia. However, existing syntheses have not differentiated positive versus negative FTD dimensions, which have distinct trajectories, mechanisms, and treatment implications. We examined the differential associations of positi...
Clara Benedetta Caterina Soldovieri, D. Elleuch, Jessica Ahrens et al.· Schizophrenia Research· 0 citations
It is suggested that cumulative illness burden is a key factor associated with brain structural decline in MDD, while also suggesting potential reversibility in more favorable disease courses.
A. Kraus, J. Goltermann, T. Borgers et al.· JAMA Network Open· 0 citations
The moderating effect of CR on the brain network-cognition association provides a neurobiological rationale for this vulnerability and supports incorporating CR into routine clinical assessment to guide risk stratification and personalized treatment planning.
M. Gruber, Henrike Renaud, M. Mauritz et al.· Psychotherapy and Psychosoma...· 0 citations
Major depressive disorder (MDD) has been associated with accelerated structural brain aging, yet whether this reflects a pre-existing neurobiological vulnerability, a dynamic acute state effect, or an accumulating biological residual remains unresolved. Across two longitudinal cohorts (N=3220), including a unique sampl...
M. Konowski, A. Kraus, J. Goltermann et al.· medRxiv· 0 citations
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