Background/Objectives: Recent evidence has suggested a transcriptional reduction in Kv7 potassium channels in the CA1 area of acquired experimental epilepsy, but presynaptic Kv7 channels might be spared. Here, we tested the influence of the Kv7 channel blocker XE991 on two forms of short-term plasticity, which are supp...
Emma Schnell, Steffen Müller, Rüdiger Köhling et al.· Brain Science· 0 citations
Introduction The non-inactivating potassium channels Kv7.2 and Kv7.3 contribute to the neuronal resting membrane potential and regulate neuronal excitability. Previous studies have indicated a transcriptional downregulation of these channels in temporal lobe epilepsy, both in patients and in the pilocarpine-induced ani...
E. Nissen, T. Kirschstein, Astrid Bertsche et al.· Frontiers in Neurology· 1 citation
The findings indicate that the APPswe/PS1dE9 mouse model does not exhibit evidence of major integrative brain clearance impairment, despite this being a hallmark of sporadic AD in humans and suggest limitations of this model for studying clearance-related mechanisms of late-onset AD should be acknowledged when planning...
L. Müller, Charlotte Köhler, T. Lindner et al.· Fluids and Barriers of the C...· 0 citations
Aims To explore the mechanisms involved in esophageal body longitudinal muscle contraction induced by electrical field stimulation. Methods Isometric contractions of esophageal segments from wistar rats in an organ bath were induced by electrical field stimulation (duration 1 s, frequency 1-100 Hz, intensity 30-90 V) b...
Michelle Gräfe, Julius-Neven Kriese, T. Kirschstein et al.· Frontiers in Physiology· 0 citations
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