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Author

T. Kleinz

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Open access Sep 2026

α-Synuclein Seeding Discriminates Between LRRK2 G2019S Variant Carriers with and Without Parkinson's Disease.

BACKGROUND Reliable biomarkers for Parkinson's disease (PD) pathology detection are essential for research. α-Synuclein (aSyn) seed amplification assay (SAA) is a validated biomarker for misfolded aSyn. OBJECTIVE The aim was to assess the association between aSyn SAA and LRRK2-related PD (LRRK2-PD) and its link to mi...

Theresa Lüth, C. Gabbert, T. Kleinz et al. · 0 citations
Open access Sep 2026

Unified long-read panel for Parkinson’s and repeat expansion disorders

Adaptive sampling is a versatile genetic diagnostic tool in neurodegenerative disorders, while enabling cost-effective multiplexing, and further validation and improvements in bioinformatic analysis are needed.

A. Fienemann, J. C. Prietzsche, Joshua Laβ et al. · 0 citations
Open access Aug 2026

The VPS35 p.A320V variant segregates with Parkinson's disease in a pesticide-exposed family

While VPS35 p.A320V co-segregated with PD in this family, it did not exhibit the characteristic LRRK2-associated biomarker signature observed in VPS35 p.D620N carriers, it is possible that p.A320V exerts a subtle effect on VPS35 function that was not captured by the assays performed and that chronic pesticide exposure...

S. Glendinning, J. Arbelo-González, L. Díaz-Feliz et al. · 0 citations

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