Clonal hematopoiesis of indeterminate potential in metastatic colorectal cancer: bidirectional regulation, systemic selection, and translational strategies
Clonal hematopoiesis of indeterminate potential (CHIP) is an age-related condition characterized by the expansion of hematopoietic stem cells harboring somatic mutations in the absence of overt hematological malignancies. Traditionally, CHIP has been viewed either as a driver of systemic inflammation or as a source of...